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硫酸庆大霉素Gentamycin Sulfate

 

1. 基本信息

中文名称:硫酸庆大霉素

英文名称:Gentamycin Sulfate

CAS1405-41-0

EINECS 号:215-778-9

常用分子式:C21H45N5O11S

分子量:547.6207

pH3.5-5.50.1%in H2O

熔点:218-237

溶解性:溶于水(50mg/ml in H2O)不溶于乙醇,丙酮,氯仿,醚等。

2. 作用用途

该品为氨基糖甙类广谱抗生素,对多种革兰阴性菌及阳性菌都具有抑菌和杀菌作用。对绿脓杆菌、产气杆菌、肺炎杆菌、沙门氏菌属、大肠杆菌及变形杆菌等革兰阴性菌和金葡菌等作用较强。

该品的作用机制是与细菌核糖蛋白体亚单位上的特异性蛋白牢固结合,干扰核糖蛋白体功能,阻止蛋白质合成,并引起翻译信使核糖核酸(mRNA)上密码的错误而合成无功能蛋白质。

临床上用于金葡菌、绿脓杆菌、大肠杆菌、痢疾杆菌、克雷白杆菌、变形杆菌和其它敏感菌所引起的败血症、呼吸道感染、胆道感染、化脓性腹膜炎、颅内感染、尿路感染及菌痢等疾患。

3. 贮藏条件

密闭,在凉暗处保存。

Gentamycin Sulfate

 1.Basic Information

TypeChemical Drug

Chinese NameLiusuan Qingdameisu

English NameGentamycin Sulfate

CAS1405-41-0

EINECS Number215-778-9

Common Molecular FormulaC21H45N5O11S

Molecular Weight547.6207

pH3.5-5.50.1%in H2O

Melting Point218-237

Dissolubilityfreely soluble in water50mg/ml in H2O, practically insoluble in alcohol, in acetone and in ether.

 2 Medical uses

Gentamicin is an aminoglycoside antibiotic composed of a mixture of related gentamicin components and fractions and is used to treat many types of bacterial infections, particularly those caused by Gram-negative and Gram-positive organisms such as Pseudomonas aeruginosa, aerogenes, Klebsiella pneumoniae, Salmonella, E. coli and Proteus.

Gentamicin is a bactericidal antibiotic that works by binding the 30S subunit of the bacterial ribosome, interrupting protein synthesis.

And it is used for sepsis, respiratory infections, biliary tract infection, purulent peritonitis, intracranial infections, urinary tract infections and dysentery and other diseases caused by Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Shigella, Klebsiella, Proteus.

3 Storage

 Be airtightstored at a dark and cool place.

 
 
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